Immuno-Oncology Scientist

Location: South San Francisco, CA

Department: Discovery

Type: Full Time

Min. Experience: Mid Level

Hi, we’re Second Genome.

We are a fast-paced and innovative venture-backed biotechnology company seeking tomorrow’s breakthrough therapeutics at the interface of complex microbial communities and their host environments.  We are leaders in microbial ecology, metagenomics, and computer science. We love fresh approaches, we value process validation, and we welcome peer review.

In addition to our ground-breaking technology, we believe in embodying an authentically joyful workplace. Our Core Values:

  • We are Innovators
  • We are Driven to Action
  • We are Great Colleagues
  • We Work Smart
  • We Respect the Data

And we’re looking for an Immuno-Oncology Scientist to join our team.

We’re on the search for an IO Scientist with a passion for tackling new challenges. We’d love to work with someone who is personally driven but comfortable not having all the answers; resourceful when working toward goals; accepting of the changing demands of the industry environment, and a natural multi-tasker. Our candidate has a PhD degree (or equivalent) with 1-3 years of relevant postdoctoral experience in immunology, immuno-oncology and/or related disciplines. We deeply value team players who understand the importance of communication and the balance between compromise and assertion.

Responsibilities and Duties

  • Assume role as a research expert to drive drug discovery and novel translational research focused on leveraging the microbiome’s influence on tumor immunology
  • Design, prioritize, and execute appropriate functional assays
  • Develop and implement novel experimental protocols
  • Communicate findings and interpretation of results both internally and externally
  • As part of a research team, define project objectives and prioritize experiments accordingly

Qualifications and Skills

  • Deep knowledge and expertise in immunology or oncology. Focus on tumor immunology research is a plus.
  • Proven contributions to research in the field of immune-cell metabolism and/or immune effector functions in the tumor microenvironment
  • Strong background and hands-on experience in the design and interpretation of in vitro and in vivo experimental models that include, but are not limited to
    • rodent and human primary cell-based assays;
    • explant culture systems;
    • 3D organoid systems and/or
    • pre-clinical animal tumor models
  • Experience with routine laboratory analysis methods, including PCR, ELISA, Western blotting, FACS, RNA-seq, etc.
  • Strong written and oral communication skills
  • Ability to thrive in a cross-functional, collaborative research environment
  • Ability to support multiple projects and meet ambitious goals and timelines

Bonus Qualifications

  • Scientific know-how of, or demonstrated interest in, stromal-immune cell interactions in the tumor microenvironment
  • Experience with human tissue-based models
  • Experience with (in vitro and in vivo) pharmacology, target assessment and translational biomarkers
  • Analysis and interpretation of microbe-host interactions, particularly microbial regulators of the host immune response

What’s it like to work at Second Genome?

We understand and appreciate the hard work and emotional investment on the part of all our team members - it takes a lot to be a contributor at a startup that’s leading its industry. We make it a priority to mindfully design our work environment and employee offerings with our unique and dedicated team in mind.

  • Competitive salary and employee stock options.
  • Fully stocked kitchen with sandwich materials, organic snacks, coffee (Peet’s or Stumptown - take your pick!) and beverages.
  • Four weeks paid time off, plus federal holidays.
  • Generous and comprehensive medical, dental, and vision plan options, including doctor house calls and in-office clinics.
  • 401(k) plan, HSA option, and pre-tax FSA accounts: dependent care, transit, healthcare, and parking.
  • Our WellBiome health and wellness program: a monthly health stipend, open standing desks, and weekly boot camp and yoga classes on-site.
  • Apple computer + all its fancy accessories
  • Friendly and open office environment with great colleagues and an intentional culture that drives innovation, passion, collaboration, and fun!
  • A picture is worth a thousand words. Check out our Instagram @secondgenomelife for a glimpse into our unique team culture.
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